so dr? i interpret from your blog that 5a reductase is responsible for MPB and sensitivity of the receptors have nothing much to do with such catastrophe?
Male pattern balding MPB is not a catastrophe. It is the cards that we are dealt when we are born just like the color of your eyes, shape of your nose, or the way you look. As stated in numerous posts, GENETIC inheritance is responsible for male pattern balding.
One of the mechanism of this genetic predisposition we know of is dihydrotestosterone (DHT). There may be other mechanisms other than DHT but it has not been discovered.
Scientists have found that if you block DHT, male pattern balding can be altered/ halted/ slowed/ temporarily reversed. Male pattern balding is not curable but it can be managed with drugs or surgery.
Blocking DHT is accomplished (as we know it) by slowing down the production of DHT. This is accomplished by inhibiting an enzyme called 5a reductase. 5a reductase is responsible for producing DHT from Testosterone. I suppose there may be another way to block DHT by blocking the receptors for DHT (not the enzyme that produce DHT). This will be new type of drug – yet to be discovered. Another drastic way to address MPB is castration to stop most of the testosterone production thus stopping most of DHT production but this will be drastic.
My point here is that it isn’t about DHT or 5a reductase. It is a genetic issue. So for those looking to completely block DHT with stronger medication such as Dutasteride (Avodart), it does not work as one may hope. Mainly because (I say again) it is a genetic issue. Another way to put it is that if you do not have the genes for MPB, you can have a very high DHT level and you will not be bald.