Does minoxidil deplete collagen levels, hence making the face appear comparatively older over time?
There is an interesting scientific paper showing some impact of minoxidil on collagen synthesis: Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells. These studies are not in humans, but may very well translate. That being said, I did a brief Google search and couldn’t find reports of minoxidil users looking well beyond their years after using the drug, and considering it has been marketed as a hair loss treatment for 20+ years, I’d say the old face look from the medication isn’t likely.
Thanks for the question. I continue to learn a great deal and realize how little I know in the grand scheme of things.