Hi Drâ€¦.Great blog.
Dr.Cotsarelis’s recent discovery about PGD2 and hair loss raises some interesting questions. Niacin (or Niaspan which is a prescription drug) increases pgd2 in the skin which I found doing some searching. (See here)
I’m very interested in the fact that the niacin flush significantly increases pgd2 levels in the skin. I would really think if high levels of pgd2 cause (possible) hair loss than how can Niapsan not show high degrees of hair loss as a side effect? It actually doesn’t list it as a rare event. The amount of studies and people taking Niaspan prescription should give doctors a massive pool of people to research regarding hair loss from PGD2 increase at the skin level. And one would think if increase PGD2 causes hair loss then we would be hearing this a lot regarding the drug Niaspan. I also couldn’t find any cases of hair loss related to Niacin toxicityâ€¦..can you?
Oddly we know that Niacin increases blood flow to capillaries, which one would think could help hair loss even though blood flow isn’t a major contributor to hair loss.
My second question is regarding high cholesterol and tryglecerides in general. If one has very high blood fats in theory could that drastically decrease blood flow at the scalp capillaries and veins by clogging them upâ€¦ leading to diffuse hair loss over the entire scalp as seen some times with FPB and DUPA. If so wouldn’t reducing the blood fats to normal levels re-establish blood flow to these areas and possibly restoring lost hair.( I understand this would do nothing to pattern loss, I’m speaking mostly of diffuse.)
These sound like bits of information and theories… not really questions for me to address. I don’t fully understand the role PGD2 plays in hair loss or the possible cause(s) of DUPA. I did find your info interesting, but they are nothing that I can act upon in my practice at this time. Perhaps someone that has researched this more would like to theorize with you in the comments…