I used Proscar in the past and it worked well in stopping hair loss and improved hair growth. I stopped it a couple years ago when I got married because my wife thought she would or could get cancer if any of my semen got inside her or even touched her (because of Mercks disclaimers about potential affects on a male fetus). She is very paranoid with tremendous anxieties, so I stopped using it. My hairloss increased greatly. I want to use it again but she is very stubborn and says “no sex if I do.” Can you tell me if there is any potential that my semen can harm her in anyway if I am taking Proscar or Dutasteride or any other Alpha blocker?
There is no evidence that women are at any risk from men who take Propecia, Proscar, or Avodart. This includes any fluid pass through from sperm (intercourse) or saliva (kissing). With regard to Propecia, the drug company has already cleared the drug for young men and the FDA would have never released it without appropriate warnings if any of the medication passed from man to woman.
Now with that said, what I am suggesting is that taking medications that impacts your wife to such a degree as you outlined above, is probably not worth the therapy that it may require or the potential to ruin your marriage. If you push on this, then you may create an unhealthy marriage.
If you find the balding option not acceptable and the medication something that does not work for you and her as a long term couple, then hair transplants are worth exploring. You are not alone, as many men find it unacceptable to take medication on a long term basis (even with my belief and the FDA assurance that the drug is safe in the long term for women who have sex with men taking Propecia). Hair transplants are good options for someone like you, assuming you qualify.